Proteoglycans can mediate renal lipoprotein retention
نویسندگان
چکیده
منابع مشابه
Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans.
The heparan sulfate proteoglycan (HSPG) syndecan-1 (SDC1) acts as a major receptor for triglyceride-rich lipoprotein (TRL) clearance in the liver. We sought to identify the relevant apolipoproteins on TRLs that mediate binding to SDC1 and determine their clinical relevance. Evidence supporting ApoE as a major determinant arose from its enrichment in TRLs from mice defective in hepatic heparan s...
متن کاملDeprenyl Can Mediate Neuronal Protection Rather than Neuronal Rescue
Background and Objective: Deprenyl is a drug for the treatment of Parkinson’s disease, where the dopaminergic neurons are the target of this drug. Several reports also documented that deprenyl has an effect on the sensory and motor neurons. There are some reports about the mode of action of deprenyl on m...
متن کاملBasement Membrane Zone Collagens XV and XVIII/Proteoglycans Mediate Leukocyte Influx in Renal Ischemia/Reperfusion
Collagen type XV and XVIII are proteoglycans found in the basement membrane zones of endothelial and epithelial cells, and known for their cryptic anti-angiogenic domains named restin and endostatin, respectively. Mutations or deletions of these collagens are associated with eye, muscle and microvessel phenotypes. We now describe a novel role for these collagens, namely a supportive role in leu...
متن کاملLipoprotein Lipase Increases Low Density Lipoprotein Retention
Lipoprotein lipase (LPL), the rate-limiting enzyme for hydrolysis of plasma lipoprotein triglycerides, is a normal constituent of the arterial wall. We explored whether LPL affects (a) lipoprotein transport across bovine aortic endothelial cells or (b) lipoprotein binding to subendothelial cell matrix (retention). When bovine milk LPL was added to endothelial cell monolayers before addition of ...
متن کاملHeparan sulfate proteoglycans mediate interleukin-7-dependent B lymphopoiesis.
Heparin/heparan sulfate proteoglycans (HSPGs) have the potential to bind and directly regulate the bioactivity of hematopoietic growth factors including interleukin-7 (IL-7), a cytokine critical for murine B-cell development. We examined the consequence of manipulating soluble heparin and cell-surface heparan sulfate to IL-7-dependent responses of B-cell precursors. Soluble heparin was found to...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Diabetologia
سال: 2006
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-006-0181-z